Formations of (5-Hydroxy)indoleS-(–)-lactic Acid,N-Acetyl-5-hydroxy-L-tryptophan, and (5-Hydroxy)indole Carboxylic Acid in the Metabolism of Tryptophan and 5-Hydroxytryptophan byChromobacterium violaceum

Tryptophan and 5-hydroxytryptophan for depression.

BACKGROUND 5 Hydroxytryptophan (5-HTP) and tryptophan are so-called natural alternatives to traditional antidepressants, used to treat unipolar depression and dysthymia. OBJECTIVES To determine whether 5-HTP and tryptophan are more effective than placebo, and whether they are safe to use to treat depressive disorders in adults. SEARCH STRATEGY Trials were searched in computerized general (M...

The dietary supplement 5-hydroxytryptophan and urinary 5-hydroxyindole acetic acid.

Incorporation of 5-methyl- and 5-hydroxy-tryptophan into the protein of Bacillus subtilis.

Addition of the tryptophan analogues 5-methyl-tryptophan, 5-hydroxy-tryptophan, and 7-aza-tryptophan, during tryptophan starvation of a tryptophan auxotroph of Bacillus subtilis, stimulated amino acid incorporation. Two of the analogues tested, 5-methyl-tryptophan and 5-hydroxy-tryptophan, competed with each other, but their addition did not prevent tryptophan incorporation into acid-insoluble ...

Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals

     Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...

Effect of Skimmed Milk on the Absorption and Metabolism of 5-Fluorouracil (5-FU) in Animals

     Several modalities of drug administration have been investigated to improve bioavailability and to reduce 5-FU related toxicity. The aim of present study was to evaluate the effect of skimmed milk on the absorption and metabolism of 5-FU in rabbits, mice and dogs. It was further aimed to determine its route related toxicity in rabbits.    Plasma concentration of both 5-FU and its metabolit...